RIGI and viral infectious disease: Innate immunity acts as the first line of host defense against virus infection by recognizing NDV infection via pattern recognition receptors (PRRs) like RIG-I (retinoic-acid inducible gene I) (Kato et al., 2006; Sun et al., 2013), MDA5 (melanoma differentiation-associated) (Rue et al., 2011), and TLR3 (Toll-like receptor 3) (Cheng et al., 2014).