The results showed that ERβ protein decreased to 64% as a result of HG(4d)+LG(4d) treatment compared to the LG(8d) group, and infection of ERβ lentivirus (↑ERβ) increased ERβ expression to 216%, while either SOD2 lentivirus infection (↑SOD2), or ERβ agonist (DPN) treatment showed no effect. This evidence concerns the gene ESR2 and lentivirus infection.