The results showed that HIF1α mRNA levels have no significant changes in different treatments, while the VEGF mRNA levels decreased to 39% as a result of HG(4d)+LG(4d) treatment, and the infection of either ERβ lentivirus (↑ERβ) or SOD2 lentivirus (↑SOD2), or ERβ agonist DPN increased VEGF mRNA to 136, 162, and 115%, respectively compared to the LG(8d) group. The gene discussed is HIF1A; the disease is infection.