The results showed that HIF1α transcriptional activity decreased to 53% as a result of HG(4d)+LG(4d) treatment compared to the LG(8d) group, and the infection of either ERβ lentivirus (↑ERβ) or SOD2 lentivirus (↑SOD2), or ERβ agonist DPN treatment, completely restored this effect. This evidence concerns the gene ESR2 and infection.