It showed that HIF1β binding ability was decreased to 36% by HG(4d)+LG(4d) treatment compared to LG(8d)) group, and this was completely restored by either infection of ERβ lentivirus (↑ERβ) or SOD2 lentivirus (↑SOD2), or ERβ agonist (DPN) treatment. The gene discussed is ESR2; the disease is infection.