The results showed that the activity decreased to 51% as a result of HG(4d)+LG(4d) treatment compared to the LG(8d) group, and the lentivirus infection of either ERβ (↑ERβ), SOD2 (↑SOD2), or ERβ agonist (DPN) treatment increased SOD2 enzyme activity by 137, 124, and 142%, respectively. This evidence concerns the gene SOD2 and lentivirus infection.