ESR2 and infection: The results showed that HIF1α protein levels have no significant changes under different treatments, while the VEGF protein level decreased to 41% as a result of HG(4d)+LG(4d) treatment, and the infection of either ERβ lentivirus (↑ERβ) or SOD2 lentivirus (↑SOD2), or treatment of ERβ agonist DPN, increased VEGF protein to 143, 187, and 113%, respectively compared to the LG(8d) group.