The results showed that VEGF reporter activity decreased to 56% as a result of HG(4d)+LG(4d) treatment, and the infection of either ERβ lentivirus (↑ERβ) or SOD2 lentivirus (↑SOD2), or ERβ agonist DPN, increased VEGF reporter activity to 139, 136, and 115%, respectively compared to the LG(8d) group. This evidence concerns the gene ESR2 and infection.