Further functional studies to elucidate the mechanism of action of ANGPTL5, such as establishing its role in lipoprotein lipase activity, are needed to confirm its involvement in obesity and T2D and may support its apparent importance in TGL metabolism and as an indicator of a pre-T2D and predictor of T2D. Here, ANGPTL5 is linked to obesity due to melanocortin 4 receptor deficiency.