In subjects without T2D, we observed that obese subjects had a significantly higher levels of ANGPTL5 compared with non-obese (mean ± SEM: 5.12 ± 0.37 vs. 4.03 ± 0.27 ng/mL; P = 0.003; Figure 2A). The gene discussed is ANGPTL5; the disease is type 2 diabetes mellitus.