The keywords “acromegaly,” “endothelium,” “cardiovascular,” “stiffness,” “intimal medial thickness,” “IMT,” “flow mediated dilatation,” “FMD,” “aneurisms,” “microcirculation,” “atherosclerosis,” “endothelial cell,” “Growth hormone,” “GH,” “insulin-like growth factor 1,” “IGF-1” were used in various combinations. The gene discussed is GH1; the disease is acromegaly.