HAVCR1 and Tangier disease: While SS mice displayed common renal manifestations of SCD, i.e., glomerular hypertrophy (Elfenbein et al., 1974; Bhathena and Sondheimer, 1991), interstitial fibrosis (Walker et al., 1971; Alhwiesh, 2014), iron overload (Walker et al., 1971; Buckalew and Someren, 1974), and KIM-1 overexpression (Sundaram et al., 2011; Hamideh et al., 2014) – a specific marker of tubular injuries – RAP treatment minimized kidney injuries in these mice.