Some lines of studies have demonstrated that HO-1 could be upregulated via adenovirus- and retroviral-mediated gene transfer in vivo, exerting its anti-inflammatory effects in inflammation and immune disorders (Otterbein et al., 1999; Chauveau et al., 2002; Liu et al., 2006; Abraham et al., 2007; Cao et al., 2011; Petersen et al., 2011; Cao et al., 2012). Here, HMOX1 is linked to immune system disorder.