FOXP3 and colitis: Additionally, HO-1 is induced to downregulate retinoic acid-related orphan receptor γt expression and IL-17A levels, while promoting the expression of Treg-related forkhead box p3 (Foxp3) and IL-10 level in dextran sulfate sodium (DSS)-induced acute murine colitis (Zhong et al., 2010; Zhang et al., 2014).