μm-PEA improves learning and memory, ameliorates depressive and anhedonia-like phenotype, reduces Aβ formation and phosphorylation of tau proteins, promotes neuronal survival in the CA1 subregion of the hippocampus, normalizes astrocytic function, rebalances glutamatergic transmission, and restrains neuroinflammation, especially in young early-symptomatic 3xTg-AD mice. Here, MAPT is linked to Alzheimer disease.