Changes in neuronal activity/signaling in AD can promote the β-amyloidogenic pathway of amyloid precursor protein (APP) processing, leading to increased Aβ levels and thus creating a sort of a positive feedback or a vicious cycle to accelerate AD pathogenesis (Herrup, 2010; Wirz et al., 2014; Cai and Tammineni, 2017). The gene discussed is APP; the disease is Alzheimer disease.