In STZ plus HFD-induced diabetic model, berberine regulated TLR4/MyD88/NF-κB signaling pathway in intestinal tissues (Gong et al., 2017) and promoted the expressions of glutamine-induced glucagon-like peptide-2 (GLP2) and tight junction protein zonula occludens 1 (ZO1), resulting in significant recovery of intestinal villus/mucosa structure and less infiltration of inflammatory cells, amelioration of intestinal barrier abnormalities, and endotoxemia (Shan et al., 2013). This evidence concerns the gene GCG and serum lipopolysaccharide activity.