The activation of PRR by its agonists is relevant, given the evidence that shows that in diabetes, there are high levels of circulating prorenin (Franken et al., 1992; Chiarelli et al., 2001) and upregulation of the PRR (Huang and Siragy, 2009; Huang and Siragy, 2010). The gene discussed is ATP6AP2; the disease is diabetes mellitus.