MAPT and Alzheimer disease: Thus, AD vulnerable neurons go from intracellular Aβ42 increases evident at cell soma, progress to pathological Aβ aggregation at terminals, somatodendritic tau aggregation and hyperphosphorylation, and eventually cell death of vulnerable neurons, including entorhinal cortex (ERC) layer 2 stellate neurons, basal forebrain cholinergic neurons and noradrenergic projection neurons in the locus ceruleus, among others.