The ability of IVM to disrupt PPI function via P2X4R potentiation (Bortolato et al., 2013) as well as the reduced PPI function in the P2X4R KO mouse model (Wyatt et al., 2013) suggests a role for P2X4Rs in pathophysiology of psychiatric disorders characterized by sensorimotor gating perturbations. Here, P2RX4 is linked to psychiatric disorder.