Moreover, we have also demonstrated that IVM can induce dysregulation in signaling molecules including DARRP-32, CaMKIIα and nNOS, all of which have been previously linked to psychiatric diseases characterized by sensorimotor gating abnormalities (Albert et al., 2002; Bernstein et al., 2005; Ishikawa et al., 2007; Frankland et al., 2008; Nasyrova et al., 2015; Wang et al., 2017). The gene discussed is NOS1; the disease is psychiatric disorder.