TAAR1 and schizophrenia: In addition, multiple genetic knockout mouse models for dopamine transporter (DAT) (Ralph et al., 2001), disrupted in schizophrenia complex (DISC) (Lipina et al., 2010) and trace amine receptor-1 (TA1) (Wolinsky et al., 2007) exhibited PPI deficits that were linked to aberrant D2 receptor activity.