How social behaviors and memory retention are specifically vulnerable to altered KCC2 function in the phospho-mutant mice, despite other behaviors such as motor function and anxiety-like behaviors being unaffected (Silayeva et al., 2015; Moore et al., 2018), also requires further investigation but may be due to differential regulation of KCC2 phosphorylation in different brain regions. The gene discussed is SLC12A5; the disease is Anxiety.