SLC12A5 and juvenile Huntington disease: Moreover, KCC2 deficits have been detected in several neurodegenerative disorders (Fuchs et al., 2010) and reducing intracellular Cl− levels can rescue memory deficits in a mouse model of Huntington’s disease (Dargaei et al., 2018), suggesting that increasing KCC2 function may be therapeutically beneficial for disorders associated with memory deficits.