We propose that potentiating KCC2 function during development to rescue the delayed EGABA shift detected in several neurodevelopmental disorders (Duarte et al., 2013; He et al., 2014; Deidda et al., 2015; Tang et al., 2016) may alleviate the complex cognitive deficits characteristic of these disorders. Here, SLC12A5 is linked to neurodevelopmental disorder.