There is a vast body of evidence not only for the symptomatic and prognostic roles but also for the pathogenetic role of a dysbalance between systemic ANGPT1 and ANGPT2 levels in conditions of severe hemodynamic destabilization and shock (such as sepsis, Systemic Inflammatory Response Syndrome (SIRS), and Acute Respiratory Distress Syndrome (ARDS)) [24–26]. The gene discussed is ANGPT2; the disease is Sepsis.