Not surprisingly, natural variants of KCNA1, KCNQ1, and KCNQ2, (KV1.1, KV7.1, and KV7.2, respectively), predicting different amino acid in the S412 position (Shaker numbering), are associated with well-known diseases involving cells excitability such as episodic ataxia, long QT syndrome, and epileptic encephalopathy26–28. This evidence concerns the gene KCNQ1 and Prolonged QT interval.