Gallen International Expert Conference of breast cancer in 2015 and 2017 [5,6], breast cancer was clinically classified into four major subtypes: triple negative, hormone receptor (HR)-negative and human epidermal growth factor receptor 2 (HER2)-positive, HR-positive and HER2-positive, HR-positive and HER2-negative (Table 1). This evidence concerns the gene ERBB2 and breast cancer.