In addition, TAMs can excrete cytokines such as epidermal growth factor (EGF), PDGF, VEGF, CCL2, CXCL8 to promote angiogenesis [29]; participate in CSF1 (secreted from breast cancer cell) and EGF (contributed by activated macrophages) feedback loop to cause metastasis [29]; and accumulate in hypoxic area [26]. The gene discussed is EGF; the disease is breast cancer.