By using a miR-210 specific reporter system, elevated miR-210 was visually proved to be transferred from hypoxic cancer cells to proximal endothelial cells via exosomes both in vitro and in vivo, which may be interceded by hypoxia-inducible factor-1α (HIF-1α) and restrain the expression of vascular remodeling related genes, like Ephrin A3 and PTP1B, to support angiogenesis and tumor growth [78,79]. This evidence concerns the gene HIF1A and cancer.