CXCL12 and neoplasm: For example, CAFs can secrete stromal-cell-derived factor 1 (SDF-1/CXCL12) [21], vascular endothelial growth factor (VEGF) [22], platelet-derived growth factor (PDGF) [18], fibroblast growth factor (FGF) [23], etc., to induce angiogenesis and promote tumor cells’ proliferation; degrade and remodel ECM by producing the members of matrix metalloproteinase family (MMPs) [24], resulting in the decrease of the ability of cell adhesion and contribute to metastasis.