The selective allosteric inhibitor compound A[19] and our potent compound MD2 share the same benzofuran parent moiety and is 7-times more potent than A. Thus, MD2 (lead compound) and other structural analogs (2-arylbenzofurans) with PTP1B can be further explored with advanced X-ray crystallography, cell-based assays, and in vivo experiments in order to confirm their functionalities and contribute to develop a therapeutic agent for T2DM. This evidence concerns the gene PTPN1 and type 2 diabetes mellitus.