SLC8A1 and cancer: We demonstrated that silencing of the NCX1 gene causes decrease of intracellular pH in hypoxic SiHa cells and that KB-R7943, a specific blocker of the reverse mode of NCX1 diminishes the abilty of SiHa, DLD1 and A2780 cancer cells exposed for 48 h to 1% hypoxia to control their intracellular pH.