TP53 and colorectal carcinoma: In this study, we focus on the inhibitory iASPP and used RNA sequencing (RNA-seq) combined with chromatin immunoprecipitation followed by sequencing (ChIP-seq) to investigate genome-wide p53 binding and transcriptional activities regulated by iASPP in the HCT 116 colorectal carcinoma cell line, which harbors wild-type p53.