By combining the gene expression profiles and Targetscan (http://www.targetscan.org/), three miRNAs, including miR-145-5p, miR-218-5p and miR-9-5p, were selected and were found upregulated in ANLN downregulated BxPC-3 cells and contained binding sites of the 3’UTR of LASP1 (Additional file 6: Figure S2B), and mostly acted as tumor suppressors [50–52]. Here, ANLN is linked to neoplasm.