Based on the GENT database, we showed that both LASP1 and RUVBL1 gene expression were significantly upregulated in pancreatic cancer tissues compared with that in normal pancreatic tissues, while RAB11B was not changed obviously, and MYO1B was significantly downregulated (Additional file 5: Figure S1A). The gene discussed is RUVBL1; the disease is familial pancreatic carcinoma.