The most common VDR polymorphisms reported to be associated with cancer and obesity are BsmI (rs1544410), ApaI(rs7975232), TaqI (rs731236), FokI (rs2228570) and Cdx2 (rs 11,568,820) [11, 12]. The gene discussed is CDX2; the disease is obesity due to melanocortin 4 receptor deficiency.