In contrast with our findings, in a randomized control trial of 60 type 2 diabetic patients, results showed that vitamin D supplementation (25 μg/d) decreased obesity indices, including WC, body fat mass and truncal fat, only in individuals with the AA genotype of Cdx2 VDR [26]. The gene discussed is VDR; the disease is obesity due to melanocortin 4 receptor deficiency.