Some viruses like Zika virus (ZIKV) [7] and West Nile virus (WNV) [8] need active p53 to facilitate their replication, while others such as adenovirus [2], vaccinia virus [9], tanapox virus [10], and human papillomavirus (HPV) [11,12,13] inhibit p53 function during their infection. Here, TP53 is linked to infection.