It acts as an immunomodulator that interferes with excessive immune responses occurring in lupus and other autoimmune diseases, and considerably slows the pathophysiological process down (reviewed in [124,125,126,127]) It was shown to directly interact with HSPA8 and to inhibit the chaperone activity of the latter [47,57]. This evidence concerns the gene HSPA8 and systemic lupus erythematosus.