AKT1 and breast cancer: CCR4-NOT transcription complex subunit 9 (CNOT9/RQCD1) has been identified as a key activator of the PI3K/AKT pathway [44], and upregulation of miR-361 in breast cancer cells can suppress its direct target RQCD1, leading to the downregulation of PI3K, AKT, and MMP-9 [22].