NFKB1 and ulcerative colitis: Such effects were also observed for another group of phenols present in EVOO, the hydroxytyrosol acetate (HTy-Ac), which, when given at the dose of 0.1% in a standard diet, was responsible for improving the clinical signs of ulcerative colitis and regulating the expression of COX-2, inhibiting the activation of NF-kβ and JNK [45].