Effects of primary prevention were reported in a sub-study associated with the Prevención con Dieta Mediterránea (PREDIMED), whereby individuals receiving MedDiet plus EVOO showed a reduction in the risk parameters of developing cardiovascular disorders, such as inflammatory cytokine (interleukin-6), the vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule 1 (ICAM-1), and an increase in high-density lipoprotein (HDL-c) levels and diminished LDL-c levels [3]. This evidence concerns the gene IL6 and cardiovascular disorder.