The following adverse events occurred in the WEC group: five cases of common cold symptoms, one case of an ankle sprain, one case of bronchitis-like symptoms, one case of mouth ulcers, one case of ovarian cystectomy, three cases of increased CRP, one case each of increased white blood cell count, TG, CPK, and uric acid levels, and two cases of positive urinary protein. This evidence concerns the gene PIK3C2A and Oral ulcer.