In comparison with their congenic littermates, AhR−/− mice developed an aggressive disease associated with a high rate mortality on day 4 (70% versus 25%), as shown in Figure 7A. Furthermore, while treatment with Mt-P protected from colitis development in AhR+/+ mice, the protective effects were lost in AhR−/− mice (Figure 7B,C). Here, AHR is linked to colitis.