Most of the hallmarks of chemoprevention, including depression of inflammation (NFκB and COX-2), induction of phase II detoxication enzymes (Nrf2), induced genomic instability (tubulin interactions), altered gene pathway expressions (increased expression of p27, cytochrome c, caspase-3 and-9, and Bcl-2-associated X, and decreased expression of cdk1, cyclin B1, BCL, FAK, RhoA, and ROCK), changes in microRNA translation, decreased proliferation and cell apoptosis (p53), impeded tumor cell invasion (Notch2), and neo-vascularization are affected by these compounds. This evidence concerns the gene NOTCH2 and neoplasm.