CYP2E1 and metabolic dysfunction-associated steatohepatitis: In this context, genetic polymorphisms of ethanol metabolizing enzymes (e.g., alcohol dehydrogenase) and cytochrome p450 2E1 (CYP2E1) activation triggering oxidative biotransformation and ROS formation, which is relevant in generating lipid peroxides, and their interference with the outcome of alcohol-induced liver disease and NASH has been discussed [134].