As very common alterations in NASH variants of the genes encoding patatin-like phospholipase domain-containing protein 2 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane-bound O-acetyltransferase domain-containing protein 7 (MBOAT7) and glucokinase regulatory protein (GCKR) were identified. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.