IGF2BP2 and obesity due to melanocortin 4 receptor deficiency: On this basis, Regué et al. could show that the global deletion of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2 or IGF2 mRNA-binding protein 2, IMP-2) lead to a resistance to obesity and fatty liver in mice treated with a high fat diet (HFD) due to reduced adiposity [81].