A2M and diabetes mellitus: Most of these multiparametric panels include biochemical markers indicating liver damage or dysfunction (AST, ALT, bilirubin, γ-GT, platelet count, haptoglobin), lipid metabolism disorders (cholesterol, triglycerides), diabetes (HbA1c, fasting insulin level), inflammation (α2M, ferritin), or provide information about matrix expression and turnover (TIMP-1, PIIINP, HA) (Figure 3).