CD40LG and myalgic encephalomeyelitis/chronic fatigue syndrome: Maes et al. reported in a study analyzing the IgM levels from the serum of ME/CFS patients, that the syndrome is characterized by an IgM-related immune response directed against disrupted lipid membrane components, by-products of lipid peroxidation, S-farnesyl-l-cysteine, and NO-modified amino acids, which are not usually detected by the immune system and, due to oxidative and nitrosative damage, have become immunogenic [58].