Considering the strong inflammatory action in leishmaniasis, the present study was designed to evaluate the association between SNPs of the IL-2 pathway and the susceptibility to the development of CL caused by L. guyanensis. However, no association was found between these polymorphisms (rs4833248, rs2069762, rs1003694 and rs3212760) and the development of CL, that is, no differences of genotypes and alleles frequencies were observed between CL cases and the control groups. Here, IL2 is linked to leishmaniasis.