While the CCR5 Δ32 deletion has extensively been confirmed to contribute to preventing initial HIV infection [1], these data may suggest that, once infection is established in patients, it does not contribute to maintaining a profound LTNP status as strongly as HCP5, HLA-B57, -A03, CCR2, or bw4/bw4 genotypes may do. This evidence concerns the gene HCP5 and HIV infectious disease.