Regarding the potential function of the 1063 genes expressed in blood associated with miR-574-3p, many significant genes were enriched in pathways involved in non-alcoholic fatty liver disease (P = 2.7x10-9) and Alzheimer's disease (AD, P = 2.2x10-7), suggesting that miR-574-3p might exert its effect through brain-related pathways, particularly neurometabolic function and chronic response to neuronal injury given the association of miR-574-3p expression with DBNDD2 and ELOVL1 gene expression in brain tissue. This evidence concerns the gene DBNDD2 and early-onset autosomal dominant Alzheimer disease.