LDLR and Alzheimer disease: For example, common low-density lipoprotein receptor polymorphisms have been tied to RNA splicing efficiency in human liver, brain, and AD.[45] Among the two genes expressed in brain tissue associated with miR-574-3p, ELOVL1 (ELOVL fatty acid elongase 1) regulates very long chain fatty acid synthesis, particularly in the brain, and inhibiting ELOVL1 with agents like fibrates reduces very long chain fatty acid accumulation in fibroblasts.[46] The second associated gene expressed in brain tissue was DBNDD2 (dysbindin domain containing 2).