GRIN2B and Epileptic encephalopathy: This is due not only to the fact that sodium channels were the first discovered epileptic genes, but also because they make up the highest constituent ratio in epilepsy genetics.[22] Other channel diseases also have attracted increasing attention in recent years such as “KCNQ2,” “KCNQ3,” “GABRG2,” “GABRA1,” “GRIN2A,” “GRIN2B,” “CHRNA4,” “CHRNB2,” and “CHRNA2”[1,21,23–25] (Fig. 6) each of which can also result in varying forms of epileptic encephalopathy, syndromes, and seizures.