DKK1 and hepatocellular carcinoma: The diagnostic value of serum DKK-1 for HCC had been previously reported.[22–31] A meta-analysis of 4 studies was conducted in 2014 to estimate the exact accuracy of serum DKK-1 for diagnosing HCC.[32] Since several studies have been published in recent years, it is worthwhile to conduct an updated meta-analysis to better understand the diagnostic value of DKK-1 for detecting HCC.