The corresponding updated meta-analysis showed 0.71, 0.80, and 0.8786 for OPN, 0.68, 0.92, 0.87 for GCP3, 0.69, 0.89, and 0.88 for DCP.[45–47] As compared to the results pooled in meta-analysis of different markers, our results with SN of 0.72, SP of 0.86 and AUC of 0.8596 in HCC diagnosis with serum DKK-1 alone might seem moderate. The gene discussed is SPP1; the disease is hepatocellular carcinoma.