In this context, a long term study showed that HLA-DRB1∗140101 was a potential risk factor to develop Hepatocellular Carcinoma (HCC) in patients with HBV.[8] Therefore, the aim of this study was to assess the association between the HLA class I and II alleles (HLA-A, -B, -C, -DR, -DR3, -DQ, and -DP) with NAFLD and its subtype, NASH. Here, HLA-A is linked to metabolic dysfunction-associated steatohepatitis.