CD30, also known as Ki-1 or Ber-H2, is a member of the tumor necrosis factor family of cell surface receptors and is a known activation antigen in lymphocytes, being rarely expressed in non-lymphoid non-neoplastic cells.[1,2] Its expression has been well studied in multiple lymphoid neoplasms including Hodgkin lymphoma,[3,4] anaplastic large cell lymphoma,[5,6] and diffuse large B-cell lymphoma,[7] among others. The gene discussed is TNFRSF8; the disease is diffuse large B-cell lymphoma.