Zhang et al[4] proposed 3 features as the criteria for AD: eczema for more than 6 months; personal and/or family history of atopic diseases; elevated total serum IgE level and/or positive allergen-specific IgE and/or eosinophilia.[4] One meta-analysis indicated that there was an inverse association between atopy/allergies and childhood ALL while no association was observed for AML or leukemia overall.[3] Compared with other AML patients, the case we reported was finally diagnosed as AML, with AD as a first manifestation and there was no report about this before. The gene discussed is IGHE; the disease is acute lymphoblastic leukemia.