PLK1 and rhabdomyosarcoma: BI2536, one of the most effective Plk1 inhibitors, induces apoptosis of rhabdomyosarcoma cells when synergistically used with microtubule-destabilizing drugs, but a low dose of BI2536 (7 nM) has no effect on C2C12 myoblasts (Hugle et al., 2015).