SERPINH1 and persistent truncus arteriosus: Systolic functional performance of the heart remained equally compromised in myofibroblast-specific Hsp47-deleted mice compared with controls, as measured by echocardiography (Figure 5F), although diastolic performance measured indirectly by tissue Doppler echocardiography indicated a lower E/e′ ratio in myofibroblast-specific Hsp47-deleted mice after TAC relative to control, suggesting that reduced fibrosis attenuated TAC-induced diastolic dysfunction (Figure 5G).