In addition, we noted aberrations in RICTOR to also significantly co‐occur with those in EGFR, which is also frequently altered in HNSCC tumors and functions at the cell surface to transduce signaling to oncogenic pathways, including the PI3K pathway (Fig. 1C) (Lawrence et al., 2015; Rodon et al., 2013). This evidence concerns the gene RICTOR and head and neck squamous cell carcinoma.