In addition, we noted aberrations in RICTOR to also significantly co‐occur with those in EGFR, which is also frequently altered in HNSCC tumors and functions at the cell surface to transduce signaling to oncogenic pathways, including the PI3K pathway (Fig. 1C) (Lawrence et al., 2015; Rodon et al., 2013). The gene discussed is PIK3CA; the disease is head and neck squamous cell carcinoma.