Using the HNSCC cohort (n = 346) from The Cancer Proteome Atlas (TCPA), it is apparent that phosphorylation of Akt Ser473 and Akt Thr308 is tightly correlated (P = 7.7526 × 10−19) in HNSCC tumors (Fig. S6a), although increased or reduced Akt phosphorylation does not appear to correlate with the presence or absence of RICTOR aberrations (Fig. S6b). The gene discussed is RICTOR; the disease is head and neck squamous cell carcinoma.