Recent studies reported that C10orf91 were related with OS on the basis of complex integrated analysis of lncRNAs‐miRNAs‐mRNAs regulatory network in oral squamous cell carcinoma,20 LINC00162 named p38 inhibited cutaneous squamous cell carcinoma associated with lncRNA which promotes growth of cutaneous squamous cell carcinoma by regulating ERK1/2 activity,21 the rest of lncRNAs were all related to cell proliferation and contribute to carcinogenesis.22, 23, 24. This evidence concerns the gene MAPK3 and oral cavity squamous cell carcinoma.