ERCC1 and cancer: Hereditary mutations in ERCC1–XPF cause several distinct human syndromes characterized by either (skin) cancer proneness, i.e., xeroderma pigmentosum (XP), developmental abnormalities and accelerated aging, i.e., XP combined with Cockayne syndrome (XPCS complex), or bone marrow failure and chromosome fragility, i.e., Fanconi anemia (FA) [1, 7–10].