KCNJ11 and cancer: Since BIR promotes accumulation of ssDNA and is implicated in cancer development, we hypothesized that ssDNA generated during BIR could serve as a substrate for APOBEC to produce mutations and kataegis. Here, using yeast Saccharomyces cerevisiae as a model, we determine whether mutagenic ssDNA is produced along different positions of the BIR track and we also characterize its potential to promote APOBEC-induced mutagenesis.