GLA and Fabry disease: Fabry disease (FD, OMIM 301500) is a rare, progressive X‐linked lysosomal storage disease caused by mutations in the GLA gene encoding the acid hydrolase lysosomal enzyme Alpha‐Galactosidase A (α‐Gal‐A, EC 3.2.1.22),1, 2 which hydrolyses the terminal alpha‐galactosyl moieties from neutral sphingolipids.3 Deficiency or absence of enzymatic activity causes intracellular accumulation of globotriaosylceramide, galabiosylceramide, globotriaosylsphingosine (Lyso‐Gb3), and associated metabolites.4, 5