By learning of that, it could be found PKM2 not only plays an important role in cytosolic glucose metabolism, but also can transfer from the cytoplasm to the nucleus rely on its c-terminal nuclear localization signal in interleukin-3, growth hormone inhibitor analogue TIT-232, peroxide, epidermal growth factor (EGFR), ultraviolet radiation and other factors, and in the form of dimers to play a role in protein kinase activity in the nucleus of a variety of transcription factors and thus affect a variety of signaling pathways to promote tumor development [114, 115]. This evidence concerns the gene PKM and neoplasm.