PKM and neoplasm: There have been many studies pointing out that PKM2 can be highly expressed in lung cancer, liver cancer, glioma, kidney cancer, etc., and there are close relationships with TMN staging, clinical stage, prognosis of patients and malignant degree of tumor, whether distant invasion and metastasis occur, etc. The more popular tumor starvation therapy that has been studied is also targeted at key enzymes of glucose metabolism including PKM2, and it is expected to effectively treat tumors [169].