SOD1 and hypertensive disorder: Their potential actions are in agreement with the current knowledge that accelerated inactivation of NO and SOD, and elevated renal damage due to increased norepinephrine, angiotensin II, endothelin, and superoxide anion, increased vascular smooth muscle cell proliferation, decreased antioxidant capacity, and are related to the hypertrophy and reduction in outer diameter of the arteries and the development of hypertension [18].