So acupuncture could achieve weight loss through appetite suppressing and calories cutting [57, 59]; (2) modulation of the neurotransmitter: acupuncture can normalize hypothalamus ingestion central functions by adjusting content of monoamine neurotransmitters including catecholamines and 5-hydroxytryptamine (5-HT) [60, 61], cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) [62], neuropeptide Y (NPY), and leptin (LP) [27, 54, 62–75]; (3) improving insulin resistance: acupuncture can increase the number and affinity of insulin receptor to improve insulin resistance (IR) status. The gene discussed is VIP; the disease is Insulin resistance.