Western blots showed protein levels of 0.43 ± 0.15-fold for SYT1 and 0.23 ± 0.14-fold for PTTG1 in somatotroph adenomas compared to the control group and restored to 0.78 ± 0.3-fold and 0.94 ± 0.15-fold in miR-423-5p+inhibitor group (Figure 4(b), p< 0.05). This evidence concerns the gene PTTG1 and acromegaly.