TAB1 and cardiac hypertrophy: Interestingly, a potential miR-140-3p target in AE-EHTs is TGF-Beta Activated Kinase 1 (TAK1/MAP3K7) Binding Protein 2 (TAB2), which forms a complex with TAB1 (TAK1-binding protein 1) and TAK1 that activates MAPK signaling and the latter has also been shown to provoke cardiac hypertrophy in vivo35.