INS and Hypoinsulinemia: STZ-treated mice that underwent HTVI of either pLIVE (STZ-pLIVE) or pLIVE-S100A9 (STZ-pLIVE-S100A9) displayed a similar degree of pancreatic β-cells loss, reduced Proinsulin mRNA level, and hypoinsulinemia (Fig. 2a–c).