DT administration caused a similar degree of severe hypoinsulinemia in RIP-DTR; Tlr4−/− and RIP-DTR; Rage−/− mice and their littermate controls with intact TLR4 and RAGE, respectively, and S100A9 overexpression did not affect this parameter (Fig. 5a, d). The gene discussed is AGER; the disease is Hypoinsulinemia.